Photocatalysis


  Jiuzhou Pharma's photocatalysis platform is dedicated to developing and expanding advanced, efficient and environmentally-friendly photochemical technologies for drug synthesis and production;

  By combining photocatalysis with continuous flow chemistry, we achieved kilogram- to 100 kg-scale production of pharmaceutical intermediates with continuous flow photocatalysis technology;

  We developed blue light and near-UV photocatalytic technologies for the synthesis of a series of bridged cyclic compounds (e.g., functionalized BCP building blocks and intermediates) and fused-cyclic and polycyclic pharmaceutical intermediates. We are also making progress in C1 chemistry to provide more and better services for drug R&D;

  Moving forward, we aim to develop methods for the synthesis of high-value building blocks and pharmaceutical intermediates through synergistic dual metal catalysis and metal-free, EDA complex-mediated photocatalysis to bridge the gap from achiral to chiral photocatalysis. By applying scientifically well-characterized photocatalysis to real-world drug synthesis, we aim to facilitate the translation of photocatalytic technologies from academia into industry.

 

 

Equipment

  Agilent Gas Chromatography (GC) System and glove box

  Parallel photoreactor

 

 

Advantages

  Efficient construction of bridged-cyclic, fused-cyclic, and polycyclic compounds. We particularly have extensive experience with [2+2] and [2+3] cycloaddition and difunctionalization of alkenes and alkynes, strained ring-opening addition, and intra-/inter-molecular HAT/HAA;

  Experience with photocatalyzed construction of C-X (e.g., C-N, C-P, C-O) bonds.;

  Independent design of novel photocatalysts (photosensitive metal complexes); basic research on photocatalytic organic synthesis and mechanisms.

Business Collaboration

Innovative Drug CDMO Services

Established Services

Human Resources

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