NO.

Product Name

Structure

Status

101

Carbamazepine intermediates

101-1

Iminodibenzyl

Iminodibenzyl (IDB)

CAS: 494-19-9

Commercial

101-2

Iminostilbene Carbonyl Chloride

Iminosulfonyl Chloride (ISBCC)

CAS:33948-22-0

Commercial

102

Carbamazepine Bromine-Free Intermediates – Bromine-Free Carbamazepine Intermediates

102-1

Iminostilbene

Iminospirobiindane (ISB)

CAS:256-96-2

Commercial

103

Oxcarbazepine intermediates

103-1

10-Methoxy Iminostilbene

10-Methoxyimino stilbene (10-MISB)

CAS:4698-11-7

Commercial

104

Paroxetine intermediates

104-1

(3S,4R)-3-(3,4-Methylenedioxyphenoxy-methyl)-4-

(4'-Fluorophenyl)-N-methylpiperidine

N-Methylparoxetine

CAS:110429-36-2

Commercial

105

Venlafaxine intermediates

105-1

1-(4-Methoxyphenyl)-2-Aminoethyl Cyclohexanol Hydrochloride

1-(4-Methoxyphenyl)-2-aminoethylcyclohexanol hydrochloride

CAS:130198-05-9

Commercial

201

Ketoprofen intermediates

201-1

2-(3-Benzoylphenyl)Propionitrile

Isopropylidenediphenylketone

CAS: 42872-30-0

Commercial

NO.

Product Name

Structure

Status

301

Gliclazide intermediates

301-1

N-Amino-Aza-3-Bicyclo[3,3,0]Octane Hydrochloride

N-Amino-azepane-3-spiro[3,3]octane hydrochloride

CAS:58108-05-7

Commercial

401

Cabapenem intermediates

401-1

(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)]

ethyl]azetidin-2-one

AOSA (4-AA) 4-Acetoxyazetidin-2-one

CAS: 76855-69-1

Commercial

401-2

Thienamycin p-nitrobenzyl ester hydrochloride (N-methylpyrrolidinone solvate)

Thiomyicin nitrobenzoate hydrochloride (N-methylpyrrolidone solvent compound)

CAS: 442847-66-7

Commercial

402

Meropenem intermediates

402-1

P-Nitrobenzyl (1R,5R,6S)-6-[(1R)-1-hydroxyethyl]-2-[(diphenylphosphonooxy)]-1-methylcarbapen-2-em-3-carboxylate

MAP [4R-[4a,5b,6b(R*)]]-3-Diphenylphosphoryloxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid p-nitrobenzyl ester
1b-Methyl carbapenem bicyclic core (hetero-nitrogen bicyclic phosphate)

CAS: 90776-59-3

Commercial

402-2

(R)-4-Nitrobenzyl-2-diazo-4-((2R,3S)-3-((R)-1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoate

(3S,4R)-4-[(1R)-1-Hydroxyethyl]-3-[(1R)-1-Methyl-3-diazo-3-p-nitrobenzylcarbonyl-2-oxo] (Meropenem Intermediate F9)

CAS:137391-68-5

Commercial

402-3

(2S,4S)-2-[(Dimethylamino)carbonyl]-4-mercapto-1-pyrrolidinecarboxylic acid-(4'-nitrophenyl)methyl ester

(2S,4S)-2-[(Dimethylcarbamoyl)-4-mercapto-1-pyrrolidinecarboxylic acid (4'-nitro)benzyl ester

CAS: 96034-64-9

Commercial

NO.

Product Name

Structure

Status

501

Sitagliptin intermediates

501-1

Boc-(R)-3-Amino-4-(2,4,5-trifluoromethyl)butyrate

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

CAS: 486460-00-8

Commercial

501-2

2,4,5-Trifluorophenylacetic acid

2,4,5-Trifluorophenylacetic acid

CAS: 209995-38-0

Commercial

501-3

3-Trifluoromethyl-[1,2,4]triazolo[4,3-a]piperazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

CAS: 762240-92-6

Commercial

501-4

(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Sitagliptin Base

(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Sitagliptin monomer

CAS: 486460-32-6

Commercial

501-5

4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-1-one

CAS: 764667-65-4

Commercial

601

Sulfasalazine intermediates

601-1

Sulfapyridine

Sulfapyridine

CAS: 144-83-2

Commercial

701

Imatinib intermediates

701-1

4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride

4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride

CAS:106261-49-8

Commercial

701-2

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-aminopyrimidine

CAS:152460-10-1

Commercial

NO.

Product Name

Structure

Status

801

Relebactam intermediates

801-1

(2S,5S)-5-hydroxypiperidine-2-carboxylic acid

(2S,5S)-5-Hydroxypiperidine-2-carboxylic acid

CAS:63088-78-8

Commercial

801-2

tert-butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1])

octane-2-carboxamido) piperidine-1-carboxylate

4-[[[(1R,2S,5R)-6-Hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-yl]carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester

CAS:1174020-64-4

Commercial

901

Avibactam intermediates

901-1

(2S,5R)-5-((4-methoxybenzyl)oxy)amino)piperidine-2-carboxamide

Commercial

901-2

(2S,5R)-6-((4-methoxybenzyl)oxy)-7-oxo-1,6-diazabicyclo

[3.2.1]octane-2-carboxamide

Commercial

901-3

tetrabutylammonium (2S,5R)-2-carbamoyl-

7-Oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl sulfate (tetrabutylammonium) salt

CAS: 1192651-80-1

Commercial

1001

Cilastatin intermediates

1001-1

(S,Z)-7-chloro-2-(1,2,2-trimethylcyclopropane-1-

Carboxamido)hept-2-enoic acid

7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid

CAS: 877674-77-6

Commercial

NO.

Product Name

Structure

Status

1101

Semaglutide intermediates

1101-1

Fmoc-Glu(OtBu)-Gly-OH (FMC)

(S)-2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoylamino)acetic acid

Semaglutide Intermediate (TTA-A20)

CAS: 866044-63-5

Commercial

1101-2

Fmoc-Lys(AEEA-AEEA-g-Glu(OtBu)-Oct(OtBu))-OH

Semaglutide Intermediate (MAT)

CAS:1662688-20-1

Commercial

1101-3

Fmoc-Gly-Arg(Pbf)-OH

Semaglutide Intermediate (FMC)

CAS: L1048377-78-1

Commercial

1101-4

Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH

Semaglutide Intermediate (TTA)

CAS:1890228-73-5

Commercial

1101-5

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu

Semaglutide intermediate (side chain)

CAS: 1118767-16-0

Commercial

1101-6

Glycine, L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-

L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycylChemicalbook

L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-

L-Tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-(parent ring)

Semaglutide Intermediate (P29)

CAS 1169630-82-3

Commercial

NO.

Product Name

Structure

Status

1201

Sacubitril intermediates

1201-1

tert-Butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropane

(2-yl)carbamate

LCZ696 intermediate

CAS:1426129-50-1

Commercial

1201-2

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)

amino)-2-methylpent-2-enoic acid

(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-[(tert-Butoxycarbonyl)amino]-2

-Methyl-2-pentenoic acid

CAS:1012341-48-8

Commercial

1201-3

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)

amino)-2-methylpentanoic acid

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-Butoxycarbonyl)amino]-2-methylpentanoic acid

CAS:1012341-50-2

Commercial

1201-4

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride

CAS:149690-12-0

Commercial

1301

Dapagliflozin intermediates

1301-1

(2R,3R,4R,5S,6S)-2-(acetoxy)methyl-6-(4-chloro-3-

(4-Ethoxybenzyl)phenyltetrahydro-2H-pyran-3,4,5-triyl triacetate

(2R,3R,4R,5S,6S)-2-(Acetyloxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)

Phenyl)tetrahydro-2H-pyran-3,4,5-triacetate

CAS:461432-25-7

Commercial

1401

Edoxaban intermediates

1401-1

tert-butyl ((1R,2S,5S)-2-amino-5-

(Dimethylcarbamoyl)cyclohexyl carbamate

[(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]...; 5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl] tert-butyl carbamate

CAS: 365998-36-3

Commercial

1401-2

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid

Edoxaban intermediate

CAS: 720720-96-7

Commercial

NO.

Product Name

Structure

Status

1501

Rimegepant Sulfate Intermediates – Rimegepant Sulfate Intermediates

1501-1

(5S,6S,9R)-6-(2,3-Difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-amine dihydrochloride

(5S,6S,9R)-6-(2,3-Difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-amine hydrochloride

CAS: 1373116-04-1

Pilot Phase

1501-2

(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol

(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohept[b]pyridin-9-ol

CAS: 1373116-05-2

Pilot Phase

1501-3

(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol: dihydrochloride

(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohept[b]pyridin-9-ol dihydrochloride

CAS: 1373116-07-4

Pilot Phase

1501-4

1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

1-(1-(1H-imidazol-1-yl-ethoxycarbonyl)pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

CAS: 1373116-06-3

Pilot Phase

NO.

Product Name

Structure

Status

1601

Olmesartan Medoxomil Intermediates

1601-1

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

CAS: 144689-93-0

Commercial

1601-2

Trityl olmesartan medoxomil

Triphenylmethyl olmesartan

CAS: 144690-92-6

Commercial